LABOKLIN is located in Bad Kissingen, Germany, and offers genetic testing for GM1-Gangliosidosis in Huskies. LABOKLIN has over 15 years of experience on genetic testing on animals. LABOGEN is a branch of LABOKLIN, with 5 years of experience. LABOGEN is specialized in testing for inherited diseases. The Disease GM1-Gangliosidosis in Huskies is a lysosomal storage disease that leads to neurological disorders. Affected dogs suffer from paralysis of the extremities and spasticity of the muscles. At the age of about 8 months most dogs die of this disease. The Trait of Inheritance GM1-Gangliosidosis in Huskies is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous).

The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease.

The mutation-based gene test and its advantages
 
The genetic defect leading to the disease has been identified. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.

Requirements
The tests are performed out of  EDTA whole blood (0.5 ml).

Testing is performed a few times per week at Laboklin.
The results are due about one week after arrival of the sample in our laboratory.